The most common reason for pain in the buttock injection is the pain caused by the reaction of the drug. Generally speaking, hormones or some anti-inflammatory and analgesic drugs are usually used for buttock injections, and local pain will rarely occur in such cases because hormones or anti-inflammatory drugs have a certain anti-inflammatory and analgesic effect, so local pain will not occur in such cases. If there is still pain, it is likely that repeated injections to the same site have led to local hematoma and thus pain. The second reason is that some nerve-nourishing drugs, such as murine nerve growth factor, are usually used in clinical practice because the concentration of these drugs is relatively high and they stimulate the local soft tissues more. After injection into the buttocks, the pain is usually localized and is more obvious when pressed by hand. Most of these cases are due to drug reactions, and the symptoms can be significantly improved after stopping the drug.