After playing hepatitis B vaccine arm with hard lumps itching can continue to observe, hot compresses, anti-infection treatment. 1. Continue to observe: after some patients receive hepatitis B vaccine, small hard lumps will appear at the vaccination site, generally without redness, swelling, pain, diameter less than 5mm, with or without itching, can continue to be observed, and can subside after a period of time. 2. Hot compresses: after vaccination with hepatitis B vaccine, if there is a large hard lump, hot compresses can be applied to reduce the swelling of the surrounding soft tissues, so that the hard lumps can subside as soon as possible. 3. Anti-infection treatment: after vaccination against hepatitis B, a little itching, scratching or rubbing, accompanied by hard lumps, redness, swelling, heat and pain, can be treated with anti-infection therapy, such as moxifloxacin (follow the doctor’s instructions for medication). After vaccination, there are hard lumps and itching on the arms, which lasts for more than three days and does not subside, or the itching, redness and swelling are obvious, then go to the hospital for consultation.