EBV generally cannot cause leukemia. EBV infection often causes infectious mononucleosis, which can be manifested as fever and sore throat, while chronic EBV infection often presents with recurrent viral infections or persistent activity, which can be associated with the development of nasopharyngeal carcinoma and lymphoma, etc. No study has confirmed that EBV infection can directly cause leukemia, and its correlation is still unclear. No study has confirmed that EBV infection can directly lead to leukemia, and its relevance is not clear.The prognosis of EBV infection is generally better after antiviral treatment. The causes of leukemia include genetic factors, environmental pollution, ionizing radiation, etc. Viral infections can also lead to leukemia, such as adult T-cell leukemia/lymphoma (ATL), which can be caused by human T-lymphotrophic virus type I (HTLV-I). However, EBV has not been found to be a cause of the disease. When EBV infection occurs, active antiviral treatment under the supervision of a doctor can lead to EBV conversion and the prognosis is good.