Tetanus vaccine is derived from animal serum, which is a heterologous protein, so there is a possibility of allergic reactions. Usually, a skin test is required before a tetanus shot is given. To determine if there is an allergy, it is mainly based on the patient’s skin and the manifestation of systemic symptoms. Injecting tetanus test allergy injection, usually at least 20-30 minutes of observation is required. Patients with allergy will usually cause localized itching, erythema, papules on the skin, and may also experience nausea and vomiting, abdominal pain, sweating, irritability, chest tightness, panic and other discomforts. Some severe patients may also develop laryngeal edema, which may even lead to breathing difficulties and anaphylaxis. The severity of the allergic reaction may vary as each person has a different degree of sensitivity to the drug. Patients who are not allergic to the injection usually do not experience any of these adverse reactions and are generally asymptomatic. After a tetanus skin test allergy, treatment can be done by injecting tetanus immunoglobulin or by performing desensitization therapy. During the recovery period, you should pay attention to your diet, avoid spicy and stimulating foods, eat fresh vegetables and fruits in moderation, and pay attention to avoid getting water on the wound, regular rest and rest, and keep the skin at the wound clean and dry to avoid infection.