After colorectal cancer surgery with chemotherapy, targeted therapy and immunotherapy, some patients can survive for more than ten years. At present, surgery is still the first choice for colorectal cancer treatment, but pure surgery has a high recurrence rate and cannot maintain a long survival period, so it is often necessary to cooperate with adjuvant treatment. Commonly used adjuvant therapies include chemotherapy, commonly used drugs include doxorubicin, gemcitabine, fluorouracil, cisplatin, carboplatin, pemetrexed, etc.; commonly used drugs for targeted therapy include bevacizumab, rimodulizumab, regorafenib, etc.; immune drugs include mainly PD-1PD-L1 inhibitors. Drugs need to be rationally applied according to medical advice. Survival period after surgery for bowel cancer is determined by many factors. It is suggested that patients should actively cooperate with the treatment, be optimistic, follow the doctor’s instructions, have regular review, monitor the condition, and adjust the treatment plan at any time due to the condition, which is conducive to improving the quality of survival and prolonging the life cycle.