The use of clotrimazole cream may appear certain hazards, including allergic reactions and transient irritation, can be manifested as erythema, papules, itching symptoms. 1. Allergic reaction: some patients have a special constitution, more sensitive to azole drugs, such patients in the use of clotrimazole cream can occur after allergic reaction, different patients allergic symptoms will be different, may appear skin erythema, papules and other lesions, accompanied by itching. 2. Transient irritation: some patients use clotrimazole cream, can cause skin irritation, can lead to patients with pimples, erythema, itching and other symptoms, but most of the symptoms of transient irritation, most of them can be relieved by themselves. It is recommended that patients use clotrimazole cream before consulting a professional doctor, do not blindly use, in order to avoid adverse reactions.