Diarrhea after simethicone can be observed temporarily if symptoms are mild; if symptoms are severe, the drug should be stopped immediately, and medication such as montelukast and bifidobacterium tetragonum tablets should be given if necessary. Simeglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with hypoglycemic, weight loss, cardiovascular benefit, etc. It is commonly used in patients with type 2 diabetes. The most common side effects of simepaglutide are gastrointestinal reactions such as nausea, vomiting, and diarrhea. After using simepaglutide, if the degree of diarrhea is mild and the duration is short, if it is tolerable, it can be observed temporarily and generally can be improved gradually; if the symptoms are serious, the drug should be stopped in time, and after stopping the drug for a period of time, it can generally recover on its own, and if the symptoms do not improve significantly, it can be treated by taking medicines such as montelukast, bifidobacterium tetrapunctate tablets, and so on. If diarrhea has not been improved after Simeglutide, you should go to the hospital to check except due to diseases, such as acute gastroenteritis, inflammatory bowel disease, intestinal tumors, etc. All medications should be administered under the guidance of a doctor.