Right lung lower lobe anterior basal segment visible vacuoles in the clinic is usually called pulmonary nodule vacuole sign, that is, in the lung nodule seen in the diameter of 1 ~ 3 mm gas density; in general, the pulmonary nodule vacuole sign may indicate tuberculosis, lung cancer and other diseases; the specific cause of the disease should be further examined and diagnosed, symptomatic and timely treatment. 1. Tuberculosis: the main symptom is cough, typically paroxysmal irritating dry cough. Tuberculosis mostly occurs in the lungs, with a slow onset and long duration of the disease, and the patients may have the condition of pulmonary nodular vacuolar sign after examination. 2. Lung cancer: the main manifestations are blood in sputum or hemoptysis, irregular chest pain or vague pain, chest tightness and shortness of breath, hoarseness, fever, and emaciation; if malignant tumor is highly suspected, it is also necessary to observe whether there are burrs, blood vessels, lobular entry in the periphery of the nodule, and whether it is accompanied by the pleural depression sign; at the same time, a biopsy should be carried out to clarify the diagnosis. Whether there are vacuoles in the lung nodules should be diagnosed according to auxiliary examinations such as nodule signs and timely treatment; if it is related to malignant tumors, early surgical resection is usually needed; always pay attention to the physical condition in daily life and seek medical treatment as soon as possible if there is any discomfort.