Lupus nephritis type IV, also known as diffuse lupus nephritis, can be treated with glucocorticosteroids (e.g. methylprednisolone) and immunosuppressants (e.g. cyclophosphamide) as prescribed by the doctor to control the activity of lupus and slow down renal lesions. Lupus nephritis type IV, also known as diffuse lupus nephritis, indicates that more than 50% of the glomeruli are involved, and is a more serious type of lupus nephritis, which requires active and standardized treatment. In the acute stage, those with obvious symptoms can first take glucocorticoid drugs such as methylprednisolone and prednisone acetate to induce remission, and after the condition is stabilized, immunosuppressants such as cyclophosphamide can be further taken for maintenance treatment. Patients with diffuse lupus nephritis usually have serious kidney damage, which can be manifested as proteinuria, hematuria, renal insufficiency, etc. It is necessary to formulate individualized treatment plan according to the patient’s symptoms, and actively cooperate with the doctor to standardize the treatment. It is recommended that patients with diffuse lupus nephritis consult a doctor in time and follow the doctor’s instructions for standardized treatment, and also pay attention to adjusting the dietary structure during the treatment process, and try to take a low-salt diet as a mainstay.