A large spleen does not always return to normal.
Splenomegaly is not an independent disease, but a clinical manifestation and sign of various disease disorders in the spleen. There are many causes of splenomegaly, including acute and chronic infections of the spleen caused by various bacteria, viruses and parasites; it can also be caused by non-infectious factors such as liver cirrhosis, portal hypertension and heart failure. Therefore, whether splenomegaly is curable depends critically on its primary cause.