The glucose-lowering drugs that can be used by teenagers include metformin, insulin and other drugs, but before using the drugs, it is necessary to distinguish whether the diabetes is type 1 diabetes or type 2 diabetes. 1. Type 1 diabetes mellitus: it occurs in adolescents and is characterized by polydipsia, polyphagia, polyuria and emaciation. The pathogenesis is due to the destruction of their own pancreatic β-cells leading to absolute insufficiency of insulin secretion and elevated blood glucose. Therefore, patients with type 1 diabetes mellitus need to use insulin for life to maintain normal life activities, and some oral drugs such as insulinotropic agents are not suitable for type 1 diabetes mellitus. 2. Type 2 diabetes mellitus: It usually occurs in middle-aged and elderly people and is a very common type of diabetes mellitus, accounting for more than 90% of the diabetic population. It is mainly caused by multiple reasons of insufficient insulin secretion or insulin resistance, resulting in elevated blood glucose. Glucose-lowering drugs can be used, such as sulfonylureas and biguanides, for example, metformin, glibenclamide, reglanatide, etc.; injectable insulin has long-acting, short-acting and intermediate-acting insulin. Teenage patients must have a clear diagnosis before using drugs, standardize the use of drugs under the guidance of the doctor, and must not use drugs on their own, so as not to cause adverse consequences.