If the pain in the lateral calf foot is caused by trauma, anti-inflammatory and analgesic drugs can be taken orally. If it is caused by vascular lesions in the lower limbs, you can take oral anticoagulant as well as blood-stasis activating drugs. Trauma caused lateral calf foot pain, you can take oral anti-inflammatory analgesic drugs to relieve pain, such as nimesulide, diclofenac sodium and so on. If it is due to lower limb vascular lesions such as venous thrombosis, varicose veins, etc., you can take oral anticoagulant drugs such as rivaroxaban, as well as proprietary Chinese medicines to activate blood circulation and eliminate blood stasis, reduce swelling and relieve pain, such as shujinzhuzhuxingxuezhu tablets, bone-setting qi ci li tablets and so on. If the lateral calf foot pain is caused by nerve compression such as lumbar intervertebral disc herniation, in addition to oral anti-inflammatory and analgesic drugs, you can also take oral neurotrophic drugs such as methylcobalamin and adenosylcobalamin. Lateral calf foot pain, in the oral drug treatment, it is recommended that patients go to the hospital, under the guidance of the doctor for regular use of drugs.