Sore hands while sleeping may be related to physiological factors, and may also be caused by cervical spondylosis, osteoporosis, rheumatic bone disease and other factors. 1. Physiological factors: If the arm is pressurized for a long time during sleep, resulting in poor blood circulation in the hand, it may cause hand soreness and pain, which may also be accompanied by hand numbness, weakness and other manifestations. 2. Cervical spondylosis: commonly found in patients with cervical disc herniation, due to improper sleeping posture or inappropriate pillow height, which may lead to protruding cervical discs compression of the local nerve roots, causing hand pain in bed, which may be accompanied by numbness of the hands, neck and shoulder pain and other symptoms. 3. Osteoporosis: common in the elderly, due to excessive loss of bone calcium in the body, easily caused by osteoporosis, resulting in a decline in the patient’s bone strength, which may lead to hand pain while sleeping. 4. Rheumatic bone disease: common in osteoarthritis, rheumatoid arthritis, rheumatoid arthritis and other diseases, if you do not pay attention to warmth while sleeping, it may cause hand soreness and pain, and may be accompanied by redness and swelling of the joints of the hands, burning and other symptoms. Sleeping hand soreness, may also be caused by other reasons, exclude physiological factors, it is recommended to seek medical treatment as soon as possible, under the guidance of the doctor standardized treatment.