Lack of bile secretion is associated with biliary obstruction, hepatitis, and malnutrition, and can be treated with surgery, medication, and improved lifestyle habits. Failure to secrete bile is related to the following factors: 1. Biliary obstruction: the most common causes are bile duct stones, bile duct inflammatory stenosis and bile duct tumor, which can cause abnormal bile excretion and bile is stagnant in the bile duct and cannot be discharged. Surgical treatment can be given, such as choledochotomy, pancreaticoduodenectomy and so on. Some of them do not meet the indications of surgery can use cholecystocentesis, endoscopic retrograde cholangiopancreatography stent implantation, etc. for bile drainage. 2. Hepatitis: the liver can secrete and excrete bile, and the secretion and excretion of bile will certainly be affected when liver function is abnormal, thus leading to cholestasis. Such as drug hepatitis, in addition to stopping the use of drugs that cause liver damage, can be given gastric lavage, magnesium sulfate diarrhea, activated charcoal adsorption and other therapeutic measures to discharge residual drugs, but also can be used to protect the liver such as polyunsaturated phosphatidylcholine and other medicines; viral hepatitis can be given tenofovir, lamivudine, tibivudine, sofosbuvir, vipatavir, daclatasvir, ribavirin, and other antiviral drugs. 3. Malnutrition: It can lead to insufficient raw materials for bile synthesis by liver cells, thus causing insufficient bile secretion. Malnutrition can be alleviated by improving lifestyle habits and adequate nutrition. The lack of bile secretion may also be caused by other reasons, and it is recommended to standardize the treatment after a clear diagnosis.