Menopause is a process in which women move from a period of normal fertility and sexual activity, through a gradual decrease in fertility and sexual activity to a complete cessation and into old age, also known as perimenopause, which occurs in most women around the age of 50 and is prominently marked by menopause. As the average female life span increases, 1/3 of the life cycle will be spent after menopause. Menopause is a transitional stage in which a woman’s ovarian function gradually declines until it disappears completely, which can lead to a variety of diseases due to abnormal ovarian hormone secretion. In this regard, experts reminded that the following types of diseases, menopausal women should pay attention to early prevention and early treatment. 1, menopause syndrome: menopause syndrome refers to a series of symptoms caused by the gradual decline or loss of ovarian function before and after menopause, resulting in a decline in estrogen levels, mainly due to plant nervous dysfunction metabolic disorders. Menstrual disorders are the most common and prominent manifestation of menopausal women. In addition, flushing, hot flashes, sweating, dizziness, tinnitus, headache, panic, increased blood pressure, depression, fatigue, memory loss, agitation, emotional instability, insomnia, irritability, frequent urination, urgent urination, painful urination, stress incontinence, discomfort during sexual intercourse and decreased libido, etc. 2, osteoporosis: After menopause, with the reduction of estrogen secretion, bone loss increases, osteoblast function is weakened, bone resorption accelerates, osteoporosis occurs, the most obvious to support the gravity of the spine, hip bone, limb bone. About 25% of menopausal women suffer from osteoporosis, and the proportion of fractures in the hip, spine and limb joints after the age of 50 is close to 40%, especially fractures in the spine and hip joints often lead to paralysis and disability. Once a fracture occurs, it indicates that osteoporosis is serious and it is difficult to recover the lost bone mass. 3.Cancer: According to statistics, the incidence of gynecological tumors increases with age, which may be related to the decline of immune surveillance and aging. The peak incidence of breast cancer, cervical cancer, uterine body cancer, endometrial cancer, ovarian cancer, etc. are in the age of 40-60. 4. Cardiovascular diseases: The incidence of cardiovascular diseases, including coronary heart disease, hypertension, hyperlipidemia, atherosclerosis, deep vein thrombosis and cerebrovascular accidents, has increased significantly in menopausal women because of the decrease in estrogen secretion in the body and the decrease in the protective effect on blood vessels. 5, diabetes: menopause and diabetes are closely related, probably due to the reduction of insulin secretion by beta cells and the increase of insulin resistance in peripheral tissues. Women without a family history of menopause may experience irregular diet and weight gain due to menopausal symptoms, thus increasing insulin resistance and increasing the risk of diabetes. For women with a history of genetic predisposition, hypertension, hyperlipidemia and obesity, menopause is more likely to result in elevated blood glucose that is difficult to control. 6. Overweight and obesity: In addition to maintaining normal female secondary sex characteristics, estrogen is also involved in the metabolism of sugar and fat. After menopause, women’s estrogen secretion decreases, and the metabolism and distribution of sugar and fat also undergoes quite obvious changes, coupled with the reduction of activities that can easily lead to obesity. Women in menopause, weight gain, and waist and abdominal fat increased to form the “apple-shaped body”, is the cause of many chronic diseases. 7, gynecological diseases: due to the decline in estrogen levels, gynecological diseases also sneak in during menopause. For example, functional uterine bleeding and vaginitis occur in about 30 percent of menopausal women. 8. Mental and neurological disorders: Menopausal women are prone to mental depression, forgetfulness, obsessive-compulsive ideas, paranoia, emotional inversion, emotional instability, persecutory delusions, anxiety, paranoia, abnormal feelings, self-consciousness and anhedonia. Some present with mania, delusional thinking and schizophrenia. So, how to take effective health care measures to improve the quality of life of menopausal women, and thus improve women’s ability to live and quality of life during menopause? 1, maintain a healthy lifestyle (1) balanced diet: recommended to eat fruits and vegetables 4-5 times a day, not less than 250g of fruits and vegetables per day, more food rich in B vitamins: such as millet, cereals, beans, lean meat, milk, leafy greens, fruits, etc.; low-fat diet, twice a week into fish food; limit the intake of salt, less than 6g / d; quit smoking and limit alcohol, daily alcohol intake of no more than 20g; drink less caffeinated beverages, appropriate amount of calcium supplementation, consumption of calcium-rich foods such as: dairy products, fish, meat, beans, vegetables, fruits, etc. (2) physical exercise: it is recommended that no less than 3 times a week physical exercise, no less than 30min each time, intensity up to medium, in order to maintain a normal weight, reduce bone calcium loss, increase bone strength, prevent osteoporosis, especially weight-bearing exercise, which helps harden the bones. Regular activities in the sun, the ultraviolet rays of the sun can make the skin synthesis VitD ability to enhance, to ensure the absorption of calcium and phosphorus in the body, delay bone aging, exercise programs including outdoor walking, climbing, running, cycling, swimming, health exercises, taijiquan, etc. (3) Keep your mood relaxed: look at menopause correctly, learn about it, actively participate in recreational and social activities, pay attention to controlling your emotions, and regulate your body and emotions through a regular life in order to safely go through menopause. 2. Hormone replacement therapy Estrogen deficiency is the core of menopause-related problems. For those whose work and daily life are affected by menopausal symptoms, hormone replacement therapy can not only control menopausal symptoms, but also reduce the occurrence of osteoporosis, lower the fracture rate of older women and prevent cardiovascular diseases. It should be noted that it should be used with caution for those with a history of embolism, chronic liver and kidney insufficiency, sex hormone-dependent tumors (endometrial cancer, ovarian cancer, breast cancer, uterine fibroids), pyrrole violet deposition, connective tissue disease, severe hypertension, diabetes, severe varicose veins, addiction to smoking, and inability to adhere to long-term follow-up. Anyone receiving sex hormone replacement therapy should have an outpatient review or letter visit every 3 months. 6 months for psychiatric examination, as well as ultrasound and endometrial biopsy if necessary. Individualized pros and cons analysis should be conducted according to the patient’s specific situation to choose the most suitable plan and obtain the maximum benefit, and regular checkups and follow-ups should be conducted to ensure effective and safe medication effects. 3. Regular medical check-ups Menopausal women need regular check-ups, health consultation and guidance about disease screening in order to achieve early detection, diagnosis and treatment. Also pay attention to the cleanliness of the vulva. For women who have started to reduce their menstruation or have just experienced menopause, this does not mean that their ovaries are no longer ovulating and contraception is still important and must not be ignored. In summary, menopausal women should pay attention to the physiological and psychological characteristics of the menopausal transition and raise their awareness of self-care in order to facilitate early detection and early resolution and improve their quality of life. Society should also pay attention to menopausal women as a vulnerable group and give them more help and reliance.