Pethidine hydrochloride is a kind of toxic anesthetic drug commonly used in clinical practice, which is also commonly known as dulcolax drug, this kind of drug is mainly applied to analgesic effect. Generally, the adult intramuscular injection is about 25-50mg, and the maximum daily dose should not exceed 600mg. For pain caused by childbirth, 25mg intramuscular injection can be given every 4-6 hours. For patients with advanced malignant tumors, the dose of injection should be administered according to the individualization of the patient, and can also be increased gradually beyond the general conventional dose to avoid patients’ drug resistance and dependence. For some patients with increased drug dependence due to induced addiction, the drug must be administered in combination with other drugs so as to avoid the problem of dependence on a single drug.