During ejaculation, the brain mainly secretes dopamine and endorphin substances, acetylcholine, gonadotropins and other substances. 1. Dopamine and endorphin substances: the brain secretes a large amount of dopamine and endorphin during ejaculation, which increases the body’s excitability and produces a short-lived feeling of pleasure. Dopamine has the effect of raising blood pressure and increasing euphoria, and endorphin substances have the effect of analgesia and increasing pleasure. 2. Acetylcholine: ejaculation will make the body sympathetic nerve excitation, the brain secretes a large number of excitatory neurotransmitter acetylcholine, thus in the excitement will appear excited, emotional excitement and so on. 3. Gonadotropins: the pituitary gland secretes gonadotropins during ejaculation, while gonadotropins stimulate the male testes to secrete androgens to increase libido and excitement. In short, dopamine endorphin substances, acetylcholine and gonadotropins are the main substances secreted by the brain during ejaculation. If you feel uncomfortable during sex, it is recommended that you go to a regular hospital in time for consultation and treatment.