Pepsinogen 2 is high and requires treatment if combined with Helicobacter pylori infection. Pepsinogen 2 is associated with gastric mucosal lesions, and high values may be associated with glandular atrophy, pyloric glandular metaplasia, and heterotrophic hyperplasia. Clinically, HP (Helicobacter pylori) testing is generally recommended first, and if positive, HP is eradicated, often with quadruple therapy (one proton pump inhibitor + two antibiotics + one bismuth agent), such as omeprazole + amoxicillin + clarithromycin + bismuth potassium citrate. If you exclude HP infection, just simple gastric mucosa mild damage can not need medication, just need to improve the diet, such as avoid eating spicy stimulating food, eat more fresh fruits and vegetables, and so on. The medication should be taken under the guidance of a doctor, and should not be used without authorization.