The precautions for playing leuprolide: 1. A slight increase in bony pain can be seen at the beginning of the medication due to the stimulation of the gonadal axis by the drug, or there may be varying degrees of urinary retention and spinal cord compression symptoms, as long as they are treated symptomatically. Because the use of this drug will cause a decrease in estrogen levels in the body, osteoporosis and bone loss will occur. Since osteoporosis often results in bone pain and joint pain, check the bone density as much as possible during the use of the drug and use the drug carefully.