Excessive growth in childhood is one of the symptoms of gigantism and acromegaly. The cause of GH overproduction is mainly pituitary GH tumor or pituitary GH cell hyperplasia, but the cause of the tumor or hyperplasia is unknown. If the secretion of growth hormone is insufficient in early childhood, pituitary dwarfism will occur; conversely, if the secretion is abnormal, the disease will start in adolescence as gigantism, in adulthood as acromegaly, and in pre-adulthood and post-adulthood as gigantism-acromegaly. The diagnosis is based on the symptoms of the slow onset of the disease, the early stage can be asymptomatic, and then gradually appear facial growth becomes broad, eyebrows and double cheek bulge, giant nose, large ears, lip and tongue hypertrophy, jaw gradually protrude, teeth sparse, nose and throat increase, blunt language, appearance tends to ugly. The fingers and toes are thick and short, the palms and plants are thick, and the skin is thick, sweaty and fatty. The thyroid gland is enlarged in a few cases, the basal metabolic rate is increased, and the thyroid function is mostly normal, but hyperactive in a few cases. The internal organs are generally enlarged, and the thorax is enlarged. Men are hypersexualized, and most women have menstrual disorders, amenorrhea, and infertility. Half of them have impaired glucose tolerance, polyhydramnios and polyuria, and those with hyperprolactinemia may have breast overflow. In advanced stages, tumor compression symptoms may include headache, visual field loss, hypertension, secondary hypothyroidism, secondary hypoadrenocorticism, gonadal atrophy and hypogonadism, osteoporosis, and limitation of spinal movement. Pituitary gigantism is characterized by excessive growth in childhood, with tall stature and particularly rapid growth of the extremities. The appetite is hyperactive and the arm strength is excessive. In the late stage (decline), the physical strength becomes weaker and weaker.