The adverse reactions of spironolactone mainly include the following aspects: 1, hyperkalemia, spironolactone belongs to a kind of potassium-preserving drugs, in the lowering of blood pressure or diuretic at the same time may be elevated blood potassium, especially with Benadryl, valsartan and other drugs when the joint application is more likely to occur. 2, the impact of the endocrine system, male long-term application of spironolactone may cause breast development, sexual function hypogonadism, or even impotence, women taking spironolactone It may cause voice coarsening, hair growth, menstrual disorders, etc. 3, gastrointestinal reactions, spironolactone has a certain stimulating effect on the gastrointestinal tract, which can cause, for example, nausea, vomiting, abdominal pain, abdominal distension, etc. 4, allergic reactions, some patients can have an allergic reaction to spironolactone, manifested as a rash, and severe respiratory difficulties can occur. 5, the nervous system, the most common, for example, headache, unsteady walking and so on.