Spironolactone is a diuretic, which in principle has the effect of preserving potassium and excreting sodium, so potassium supplementation is not routinely needed. However, it needs to be decided according to the patient’s own blood potassium situation, if itself belongs to the state of potassium deficiency, in the oral spironolactone process needs to be treated with potassium supplementation. For example, the most common disease of the urinary system is primary aldosteronism syndrome, which can cause severe low potassium and can be treated with spironolactone. Its main purpose is to prevent excessive loss of potassium from the urine so that the patient’s blood potassium does not become too low. This condition sometimes requires concomitant potassium supplementation therapy, regular monitoring of blood potassium changes, and then aggressive surgical treatment. If the treatment is only to improve edema, spironolactone is required, potassium supplementation therapy is not routinely needed, and regular monitoring of blood pressure concentrations is also required. Spironolactone is often treated synergistically in combination with other types of diuretic drugs, such as in combination with furosemide tablets. The two are both diuretic and potassium-preserving, so that hypokalemia does not occur, and so potassium-supplement therapy is not required. However, in specific disease conditions where there is low potassium, potassium supplementation is needed.