Hormone modulation generally involves the use of hormonal drugs, including estrogen, progestin or a combination of estrogen and progestin, to adjust the patient’s physical status. Hormone modulation must be indicated and not contraindicated before hormone replacement drugs can be used. The principle of hormone regulation is to supplement what is lacking. If there is a lack of progesterone, it is sufficient to supplement progesterone alone, without supplementing estrogen; if there is a lack of estrogen, it is necessary to supplement estrogen and progesterone at the same time; if the patient does not have a uterus, such as a hysterectomy, if there is a lack of estrogen, it is sufficient to supplement estrogen alone, without supplementing progesterone. Hormone regulation first requires gynecologic ultrasound and sex hormone six, and depending on the situation, hormone replacement drugs can be selected, while the patient’s medical history and clinical examination can be combined to further clarify whether hormone replacement drugs can be applied.