Taking painkillers after drinking alcohol is not advocated, and drinking alcohol after taking ibuprofen is also not advocated, because the interaction between NSAIDs and alcohol has a superimposed effect, sometimes the side effects are superimposed, the positive effect is not multiplied, but the side effects are increased. Alcohol itself has certain damage to the body, including the gastrointestinal tract, plus the biggest side effect of ibuprofen itself is gastrointestinal side effects, if ibuprofen is taken in large quantities or for a long time, serious gastrointestinal bleeding and ulcers may even occur, so it is not recommended to drink alcohol after taking ibuprofen, and it is also not recommended to take any pain medication or any other western medicine after drinking alcohol.