Generally speaking, Gentian Liver Pill and Sikai Pill can be taken at the same time, but need to pay attention to the contraindications of the drug, follow the doctor’s advice to take medication, not self-medication. Gentian Liver Pill has the effect of clearing the liver and gallbladder and inducing dampness and heat, and contains a number of traditional Chinese medicines such as gentian, chaihu, scutellaria and zedoary. Si-Xie Pill is a food elimination and stagnation-inducing (food digestion) agent, which is effective in eliminating food, qi, phlegm, water, stagnation and constipation, and contains Chinese medicines such as rhubarb, petunia seeds, and aromatic herbs. These two drugs in the composition and efficacy are not conflicting, generally can be taken together. Gentian Diarrhea and Liver Pill is suitable for conditions such as damp-heat of liver and gallbladder (damp-heat evils accumulated in the liver and gallbladder), damp-heat with menorrhagia, dystocia and bitterness of mouth (pain in the area of dystocia and ribs, and bitterness in the mouth), and tinnitus and deafness. It should not be used for a long period of time by people with weak spleen and stomach, is contraindicated for people with stomach cold and pregnant women, and should not be used together with tonic Chinese medicines. Si Xie Wan is indicated for stagnation of qi, food, phlegm and water, fullness in the chest and epigastric region, constipation, abdominal distension and pain. Si-Xie Pills should not be used if the body is weak, the spleen is deficient in loose stools, or if the patient has an external infection, or if the patient is pregnant. The side effects of Gentian Liver Disease Pill and Si-Xie Pill are not yet clear. Taking them together should be guided by a professional doctor and should not be used on one’s own.