When pituitary adenomas overgrow and cause pressure on the normal pituitary gland, or when surgery or radiotherapy damages the pituitary gland, the pituitary gland will become dysfunctional, causing imbalance in the body’s endocrine system. Often, doctors will recommend hormone replacement therapy. Hormone Replacement Therapy (HRT) is essential for your health and quality of life by supplementing the hormones that are deficient in your body to keep them at a normal physiological level and to ensure that they can maintain the normal physiological activities of your body. The most common hormone supplementation after pituitary tumor surgery is adrenal glucocorticoids. Usually, when the surgery is just finished and in the period of stress, the dose of supplement is relatively large, and the infusion is used to supplement; two or three days after the surgery, it can be transitioned to oral, and then with the recovery of pituitary function, the oral hormone is gradually reduced, and the vast majority of patients do not need to take hormones for a long period of time. Doctor’s tip: hormone overdose and underdose will affect the health of the body, the doctor will be for each patient’s situation to develop a personalized medication plan, the patient must not take or stop taking medication on their own. After surgery, the pituitary gland and thyroid hormones should be checked regularly, and the speed of reducing the dosage and the time of stopping the medication should be adjusted according to the hormone level.