In general, urine leukocyte esterase (±) usually refers to weakly positive urine leukocyte esterase, physiological increase can be seen in cases such as strenuous exercise; pathologic increase suggests the possibility of urinary tract infections, commonly found in cystitis, pyelonephritis, urinary tract infections and so on. Leukocyte esterase is a specific enzyme contained in human leukocytes, which is commonly used in clinical practice to detect the presence of leukocytes in specimens; however, leukocyte esterase only exists in neutrophils, but not in other cells. Therefore, leukocyte esterase can indicate infection. Physiologic elevations, which are common after strenuous exercise, can be weakly positive or positive for leukocyte esterase and are generally normal and do not require special treatment. If pathologic increase is suggestive of urinary tract infection, such as cystitis, pyelonephritis, urinary tract infection, etc., when the patient’s urine leukocytes increase, the test may appear urine leukocyte esterase weak positive. If you find the urine test leukocyte esterase weak positive, it is recommended to consult a doctor in a timely manner, in accordance with the doctor’s instructions to further improve the relevant examination, a clear diagnosis.