A patient woke up with a swollen mouth, in general, the common causes are mainly the following situations, I. The patient at night eating seafood, mango, tomatoes and other allergy-prone food, although at that time there is no obvious allergic manifestations. At night during sleep the organism has a delayed allergic reaction, which can be manifested as obvious swelling of the lips. At this time, patients can take oral loratadine, paracetamol and other drugs anti-allergy treatment. If the patient’s lip swelling symptoms can not be relieved, it is recommended to go to the hospital as soon as possible to the dermatology department to give anti-allergy or desensitization treatment, so as to alleviate the symptoms of lip swelling. Second, the patient was mosquito bites at night while sleeping can also cause significant swelling of the mouth. In this case, since the patient has a strong compensatory ability, the local inflammation and swelling can be reduced by taking oral medications such as Swollen Pain An and Amoxicillin. Avoid eating spicy and stimulating foods to avoid progressive aggravation of lip swelling symptoms.