Recurrence of non-functioning pituitary macroadenomas and re-surgery is risky and treatment should be carried out in strict accordance with medical advice. Pituitary adenomas are benign tumors originating from the pituitary cells in the anterior lobe of the pituitary gland. In a small percentage of patients, pituitary adenomas are malignant and metastasize, also known as pituitary carcinoma, which is extremely rare. Patients with pituitary adenomas usually experience menopause, sexual dysfunction, and facial changes. For non-functioning pituitary adenomas that recur after treatment by a surgeon, surgery can be performed. All surgeries carry certain risks, including surgery for non-functioning pituitary adenomas, including anesthesia and surgery. Surgery is an important means of treating pituitary adenomas, and it is recommended that patients should take into account their own situation and cooperate with their doctors to undergo surgery again to improve the quality of life of the patients and do a good job of post-operative care.