Middle-differentiated cancer of cardia cannot be completely cured, early stage can be surgically resected and adjuvant chemotherapy, and radiotherapy is mostly used to slow down the development of the disease in the late stage. Middle-differentiated cancer of cardia is one of the malignant tumors of cardia, which is located at the junction of esophagus and stomach. Early detection, early diagnosis and early treatment are the keys to cure. If the cancer develops into middle or late stage with distant metastasis, surgery cannot remove the tumor cleanly, and radiotherapy, chemotherapy and targeted therapy are often used. If it is early stage cardia moderately differentiated cancer, surgery can be used to remove the proximal part of the stomach and anastomose the lower esophagus and the stomach, and then radiotherapy and chemotherapy can be used to control the metastasis and spread of cancer cells. If the metastasis exists in advanced stage of middle-differentiated pancreatic cancer, radical surgery is usually not possible, and interventional therapy and chemotherapy are often used to remove the cancer cells in the body and slow down the progression of the disease. Whether or not cardia moderately differentiated cancer can be cured is related to the patient’s stage, severity with or without metastasis, etc., and treatment should be carried out under the guidance of doctors.