There is no substitute for the role played by the skull in the human body, and only under the strong protection of the skull can the brain tissue function normally. However, accidents are everywhere in life, such as traffic accidents, falling objects, etc. can lead to cranial defects. Cranial defect has a great impact, so patients should not be careless about it. The integrity of the cranial cavity is seriously damaged after cranial defect, and the intracranial environment and intracranial pressure become very unstable, which directly affects the circulation of cerebrospinal fluid and blood in the cranium, and the normal operation of brain nerve function may also be affected, thus causing a series of cranial defect syndrome. For example, patients may feel dizzy and headache, numbness and weakness of limbs, easy to be irritable, and also have vision, hearing and smell impairment, and in serious cases, epilepsy may be induced. The skull defect also seriously affects the aesthetic appearance, and the patient’s psychological burden is relatively large, which will become more inferior and depressed in the long run. In addition, without the protection of the skull, the brain can be threatened at any time, especially if it is hit by heavy objects, which can injure the brain tissue and even threaten the life. The damage caused by cranial defects should not be underestimated, and timely cranial repair surgery is critical. The current clinical use of PEEK material for skull repair surgery, the material has the advantages of three-dimensional reconstruction, similar to the autologous skull, high temperature resistance, etc., is currently the better material for repairing the skull.