Timely cranial repair after skull defect is not only beneficial to the patient’s recovery, but also can effectively avoid some cranial syndromes. If the defect is not repaired for a long time, the brain will lose the protection of the skull and will cause great damage to the brain tissue under the impact or force of external force on the head. Therefore, it is important to perform cranial repair in a timely manner regardless of the cause of the cranial defect in life. Although, skull repair as a relatively routine surgery in neurosurgery, the surgical risk is very low, and it will not cause any damage to the brain and blood vessels supplying the brain, and most of the neurosurgeons and experienced doctors will not cause any risk to the patients to complete this surgery. However, after clinical research, it is found that titanium mesh cranial repair, at present, still has some defects, and the common problems are postoperative rejection, infection, chronic pain, and material exposure, so it cannot be used as the first choice repair for patients. In recent years, with the emergence and clinical use of polyetheretherketone peek material cranial repair plastic surgery, the majority of patients with cranial defects have seen a new hope. At present, a number of minimally invasive surgeries have gained a reputation in the region for their remarkable results. In recent years, its neurosurgery department has introduced polyetheretherketone peek material cranioplasty. This technology has four technical innovations compared with the cranial bone repair surgery carried out in other hospitals, on the basis of neurosurgical repair, further plasticization is done on the appearance, which can effectively avoid the problems of temporal muscle atrophy and asymmetry on both sides after surgery by cleverly connecting the repair and plasticization together; in addition, the cranial bone repair and plastic surgery with polyether ether ketone peek material uses the new artificial material peek as the implant material, and the properties of peek are very close to those of human beings. The performance of peek is also very close to the human cranial bone, and there is basically no postoperative complications.