The common chemotherapy regimen for advanced gastric cancer is fluorouracil drugs combined with platinum or paclitaxel. Gastric cancer is a common malignant tumor in clinic nowadays, which is usually caused by factors such as Helicobacter pylori infection. The main clinical treatment for this disease is surgery, while advanced gastric cancer is mainly treated with drugs, and common chemotherapy programs include fluorouracil drugs combined with oxaliplatin or cisplatin, fluorouracil drugs combined with paclitaxel, and triple combination programs. If the patients are old and in poor physical condition, and cannot tolerate the combination of drugs, they can also take single-agent chemotherapy program of oral fluorouracil. To sum up, the main chemotherapy regimen for patients with advanced gastric cancer usually focuses on fluorouracil, and it is recommended that patients should seek medical treatment as early as possible and adopt appropriate chemotherapy regimen according to doctor’s advice.