The cost of Down’s syndrome screening in the middle of pregnancy is not standardized nationwide, but may go up or down depending on the local consumption level and the level of the hospital. Overall, the cost of Down’s syndrome screening is around 200-300 RMB, the higher the level of the hospital, the higher the fee level, you should consult the hospital for the specific cost. If the Down’s syndrome screening is done at a private hospital, it cannot be measured at this rate. It is possible that some package tests may accompany the test and raise the fee several times. It is recommended that for mid-term Down’s syndrome screening, you should consult in advance about the cost of the test on the one hand, and preferably visit a public hospital for Down’s syndrome screening on the other.