Waking up at two or three o’clock in the middle of the night may be due to an exuberant fire in the heart, and it may also be caused by other reasons such as liver yin deficiency and kidney yin deficiency. Patients with Heart Fire Exuberance may have self-consciousness of heat, insomnia and dreaminess, emaciation, thirst, constipation, sweating, and short yellowish urine, so patients may have the symptom of waking up at two or three o’clock in the middle of the night. In addition, patients with Liver Yin deficiency will also have insomnia, dreaminess, headache, dizziness, tinnitus, pain in the coarseness of the ribs, and short temper, thus patients will show symptoms of waking up at two or three o’clock in the middle of the night. In addition, patients with kidney yin deficiency may also suffer from insomnia, excessive dreaming, tinnitus, dizziness, emaciation, dry throat, and dry stools. Waking up at two or three o’clock in the middle of the night may also be caused by physiological factors such as noisy environment or sleeping environment is too cold, too hot, and it is not necessarily caused by heart fire. It is recommended that when patients often wake up at two or three o’clock in the middle of the night, they need to consult a doctor in time, and the doctor will choose the appropriate treatment for the cause of the disease.