Penile weakness can be treated according to the cause of the disease, such as prostatitis can be used levofloxacin tablets, doxycycline hydrochloride tablets, etc.; erectile dysfunction can be used avanafil, sildenafil citrate, vardenafil hydrochloride and other drugs for treatment. 1. Prostatitis: If the weakness of penis is caused by prostatitis, the treatment can use levofloxacin, tamsulosin hydrochloride extended-release capsules, doxycycline hydrochloride and other drugs for treatment. 2. Erectile dysfunction: If penile weakness is caused by erectile dysfunction, patients can be treated with drugs such as avanafil, sildenafil citrate and vardenafil hydrochloride. These drugs can increase the concentration of cyclic guanosine monophosphate, promote cavernous smooth muscle diastole, so that the blood flow in the penile artery increases, and improve the symptoms of erectile dysfunction. It is recommended that patients clarify the cause of the disease and follow the doctor’s prescription for medication under the diagnosis and treatment of a professional doctor. In addition, penile weakness may also be caused by physical fatigue, masturbation, frequent sex, psychological factors and other reasons. It is recommended to have more rest, control masturbation and sexual life, adjust psychological factors, etc., penis weakness will gradually return to normal.