High total cholesterol may be a physiological phenomenon caused by eating high cholesterol foods and does not require special treatment. It may also be due to hepatitis, cirrhosis and other diseases, patients need to follow the doctor’s instructions for drug treatment, surgical treatment and so on. 1. Physiological phenomenon: Usually patients often consume high cholesterol food, which often leads to an increase in total cholesterol, usually not more than 6.45mmol/L, which is a normal physiological phenomenon and does not require special treatment. Patients need to closely monitor the condition, and most patients can recover on their own after improving their dietary habits. 2. Hepatitis: Usually, patients need to follow the doctor’s instructions to use the liver-protecting drugs such as silymarin preparations, glycyrrhizic acid preparations, bisacodyl and so on, if the patient has liver failure, if the condition permits, it is also necessary to carry out the treatment of artificial liver support in a timely manner. For patients with end-stage liver disease and liver failure, liver transplantation can be carried out according to medical advice. 3. Cirrhosis: Usually, patients need to use antiviral drugs such as entecavir and tenofovir as prescribed by doctors, and some patients with good liver function can also use interferon. For patients with ascites, they should be treated with diuretics such as spironolactone and furosemide. In the case of patients with end-stage cirrhosis, liver transplantation is also required. If patients have complications such as ascites, gastroesophageal vein rupture and bleeding, they also need to choose to undergo transjugular vein portosystemic shunt surgery, disconnecting surgery, interventional surgery and so on under the guidance of the doctor. It is recommended that patients with high total cholesterol should find out the cause of the disease in time and treat it according to the cause.