Hepatitis B dna refers to the amount of hepatitis B virus, and the need for treatment for hepatitis B does not depend solely on the amount of hepatitis B dna, but also needs to be combined with liver function, histologic examination of the liver, family history, and the presence or absence of extrahepatic manifestations associated with the hepatitis B virus. The level of hepatitis B virus does not alone serve as a basis for determining the need for treatment; the impact of the hepatitis B virus on the infected person’s relevant organs needs to be evaluated before a decision can be made as to whether or not treatment is needed. If the liver function and histology of the liver are normal and there is no family history of cirrhosis or liver cancer, and there are no extrahepatic manifestations associated with the hepatitis B virus, even if the hepatitis B virus is high, treatment is not required. If the hepatitis B-infected person has significant inflammation or fibrosis on liver histology, treatment is needed as long as the hepatitis B virus quantification is measurable; if the hepatitis B-infected person is older than 30 years of age, there is a family history of hepatocellular carcinoma or cirrhosis, and the hepatitis B virus quantification is measurable, treatment is also needed. Treatment needs to be initiated if the hepatitis B-infected person has abnormal liver function and is positive for the hepatitis B virus, or if the hepatitis B-infected person has extrahepatic manifestations associated with the hepatitis B virus, such as hepatitis B virus-associated glomerulonephritis, and is positive for the hepatitis B virus. If a measurable viral load of hepatitis B DNA is detected, it is recommended to seek prompt medical attention and consultation with a hepatologist for a comprehensive evaluation to determine the need for treatment.