Biliary stasis is a common disease in life, and with the accelerated pace of life, more and more friends suffer from this disease, which seriously threatens the health and quality of life, and can seriously form stones or even cancer. The following let us understand the causes of its formation: Acute cholecystitis: is caused by the gallbladder duct obstruction and bacterial invasion of the gallbladder inflammation, including simple cholecystitis, purulent or gangrenous cholecystitis, 80% with gallbladder stones, is one of the common clinical acute abdominal disease. The common causes of this disease include: 1. obstruction caused by stones embedded in the gallbladder duct, bile depression in the gallbladder, and inflammation caused by concentrated bile salts damaging the gallbladder mucosa. The cause of obstruction is a basic factor causing acute cholecystitis to start 2. bacterial infection, the common causative organisms are Escherichia coli, Bacillus aerogenes, Pseudomonas aeruginosa, etc., mostly retrograde from the bile duct. 3. chemical irritation: high concentrations of bile salts irritate the gallbladder mucosa causing acute inflammation. It often occurs after trauma, or some abdominal surgery unrelated to the biliary system. In recent years, with the change of the national diet and advanced age, the incidence of gallbladder stones in urban people is significantly higher, so the incidence of acute cholecystitis is more in urban residents, the incidence of adults is high, the incidence of the elderly is higher, the incidence of obese women is high, according to statistics, female: male is 2:1. acute symptoms of this disease repeated attacks can turn into chronic cholecystitis. The current surgical treatment of this disease has a high cure rate. For simple cholecystitis with mild disease, drug therapy can be used. For purulent or gangrenous cholecystitis, surgery should be performed in time to avoid complications. Neonatal hepatitis syndrome: It is a neonatal disease caused by multiple causes and the main pathological change is non-specific multinucleated giant cell formation. It is characterized by obstructive jaundice, hepatosplenomegaly and abnormal liver function with elevated conjugated and unconjugated bilirubin in the late neonatal period, and most cases are caused by infection during or after delivery. It often develops around 1 month after birth. Broadly speaking, it includes intrahepatic bile depression of hepatocellular origin, such as infections, metabolic diseases, familial bile depression, chromosomal abnormalities and idiopathic neonatal hepatitis, while narrowly speaking, it is limited to inflammation of hepatocytes caused by infection. Multi-organ dysfunction syndrome: also known as multi-system organ failure (MSOF) or multi-organ failure (MOF), refers to the acute dysfunction or failure of more than one system or (and) organ concurrently or successively during the course of an acute illness such as severe infection, trauma or major surgery, with the lung generally being involved first, followed by the kidney, liver, cardiovascular, central system, gastrointestinal, immune system and coagulation system Dysfunction. The pathogenesis of multiorgan dysfunction syndrome is characterized by secondary, sequential, and progressive nature. Clinical types 1. Phase I rapid onset, Phase I rapid onset refers to the onset of two or more systemic organ dysfunctions 24 hours after the onset of the primary acute etiology, and this category is often particularly severe in primary emergencies. For those who die within 24 hours of onset due to organ failure, it is generally classified as a failure of resuscitation and not as MODS. 2, Phase II late onset, Phase II late onset refers to the first appearance of a systemic organ dysfunction (mostly cardiovascular or renal or pulmonary dysfunction), after which there appears to be a stable phase, followed by a period of time before the appearance of other or more systemic organ dysfunction.