Uremic patients with dull face need to be treated with adequate dialysis, correction of anemia or kidney transplantation. Uremic patients with dark complexion is mainly caused by various uremic toxins stimulating the skin to secrete melanin, and to a lesser extent, it is caused by severe renal anemia. Adequate hemodialysis or combined hemodialysis filtration and hemoperfusion can be carried out to eliminate all kinds of uremic toxins in the body as much as possible; patients with combined anemia can be treated with roxarestat. In addition, kidney transplantation is also available. Uremic patients with dark complexion is not recommended to use whitening skin care products, because such skin care products may contain hormones or heavy metal ions, will cause health hazards. Uremic patients are advised to go to regular hospitals in a timely manner, under the guidance of physicians to standardize the treatment, do not self-medication.