Rejection can also occur with a reoccurring bone marrow transplant that is fully compatible. Bone marrow transplantation is categorized into holophasic and hemiphasic transplantation. Holophasic transplantation is less likely to have rejection than hemiphasic transplantation and the degree of rejection is less severe, and the severity of rejection is related to the patient’s own condition. Therefore, after bone marrow transplantation, the patient’s organ function should be closely monitored to be alert to the possibility of rejection. The acute rejection period occurs within three months after transplantation, and the chronic rejection period occurs after three months. If rejection reaction occurs, it is necessary to take some anti-rejection drugs under doctor’s guidance, including immunosuppressants and hormone drugs, such as cyclosporine, dexamethasone, etc. After six months, if there is no rejection and then start to slowly reduce the drug, generally one year without rejection can be discontinued. If there is any discomfort such as skin rash or fatigue after bone marrow transplantation, you should consult a doctor in time for further treatment or therapy under the doctor’s guidance.