Defects in the skull can pose a great threat to life and health, so many patients pay more attention in choosing the hospital and specialist surgery for their operation. The skull is a very hard bone in the human body and plays a very important role. It protects the brain, head and facial organs of the human body, and maintains a normal and stable intracranial pressure to ensure that all life activities are carried out in an orderly manner. Therefore, if a defect occurs in the skull, it poses a great threat to life and health and should be repaired in a timely manner. In fact, in today’s medical environment, cranial repair is a relatively routine procedure in neurosurgery, which is very safe and basically risk-free. However, it is still important to choose good cranial repair materials to achieve good surgical results. Because if the material is not good, it may lead to rejection, subcutaneous fluid, chronic pain, many problems and so on. PEEK is a newly developed polymeric biomaterial that has been in clinical use for a shorter period of time than titanium mesh, but is many times more effective in clinical practice than titanium mesh. The PEEK material, which highly recreates the physiological structure of the skull, is popular with patients because it is comparable to autologous cranial bone in terms of tissue description, hardness, stability, and thermal insulation.