If liver metastasis occurs in rectal cancer, clinically, patients need to take chemotherapeutic drugs, targeted drugs, antiemetic and analgesic drugs, etc. The details are as follows: 1. Chemotherapeutic drugs: as there is no clear indication for radical surgery in advanced stage of rectal cancer, chemotherapy is needed to alleviate the symptoms and prolong the survival period of patients, and commonly used chemotherapeutic drugs include oxaliplatin, fluorouracil, tiglio, capecitabine and so on. 2. Targeted drugs: clinically recommended drugs include cetuximab, bevacizumab, regorafenib and so on. 3. Symptomatic treatment drugs: if patients have adverse reactions such as nausea and vomiting in chemotherapy, anti-emetic drugs can be applied, such as metoclopramide tablets, morphine and so on. Cancer pain may also occur in advanced stage of rectal cancer, and painkillers such as aspirin, diclofenac, tramadol, morphine, etc. can be used step by step. It is recommended to go to regular hospitals for consultation and treatment and follow the doctor’s instruction to avoid delaying the condition. Drug treatment has specific indications, dosage, and the possibility of adverse reactions, so please strictly follow the doctor’s instructions and do not use drugs on your own.