Neurontin, also known as lyophilized recombinant human brain natriuretic peptide, is a relatively new anti-heart failure drug that can rapidly improve the symptoms of heart failure and effectively stop the remodeling of the heart. It can selectively dilate blood vessels, reduce the load of heart, antagonize neuroendocrine, resist cardiac remodeling, protect cardiomyocytes, and have significant inhibitory effect on angiotensin and aldosterone system, and the inhibitory effect on neuroendocrine hormone is relatively long-lasting, with few side effects, and safe to use. It can be used in acute congestive heart failure, acute coronary syndrome, cardiothoracic surgery, pulmonary heart disease many kinds of diseases, effectively relieve the patient’s dyspnea, improve the systemic symptoms, improve the left ventricular ejection fraction, increase the urine volume, currently in the cardiology department has been widely used, and achieve good results.