Due to large individual differences, there is no specific medicine for itchy skin on legs. Itchy skin on legs may be related to dry skin, allergy, diabetic peripheral neuropathy, etc. Vaseline, Diphenhydramine, Loratadine and other medications can be given according to the cause. 1. Dry skin: especially in the autumn and winter seasons, dry weather or too frequent bathing can lead to dry skin. When the above symptoms occur, Vaseline can be used as prescribed by the doctor for topical application in order to play the role of moisturizing. In addition, drinking more water and avoiding frequent bathing can also help to relieve the symptoms. 2. Allergy: The above symptoms can also occur after allergic reaction due to contact with allergens such as chemical fiber clothing, etc. Anti-allergy treatment can be carried out with drugs such as diphenhydramine and loratadine. 3. Diabetic patients with peripheral neuropathy: diabetic patients with peripheral neuropathy can also appear local itching symptoms, at this time should be improved through the control of blood glucose and other methods, and it is recommended to go to the hospital in a timely manner to avoid delays in the condition. The above drugs should be used in accordance with the doctor’s instructions, if the symptoms of itchy skin on the legs are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner, to identify the cause of the targeted treatment.