Sore throat in the middle of the night, this situation is mainly seen in the following diseases: 1. Inflammation of the throat. In addition to pain, this condition may also have a dry throat and other discomfort. Common diseases include acute tonsillitis, acute pharyngitis, chronic pharyngitis, chronic tonsillitis, acute epiglottitis and other such diseases. In this case, the patient can be sent to the emergency ENT department for examination, which can see the manifestations of congestion, infection, and suppuration in the throat. Clinical according to the patient’s situation, can be symptomatic treatment with pharyngitis drugs; 2, if the patient has a very serious local septic inflammation, white blood cells and neutrophils significantly elevated, you can apply antibiotics and other symptomatic treatment, you can do nebulization treatment; 3, individual cases are relatively rare, some patients have coronary heart disease induced by heart ischemia, there may be performance of the painful feeling in the throat, this situation to Special attention should be paid to this condition. Patients are advised to do routine electrocardiogram and cardiac enzyme profile to avoid accidents.