Osteoarthritis, plantar fasciitis, metatarsal head osteochondromatosis, gout and other causes are considered. 1. Osteoarthritis: Joint degeneration, hyperplasia and narrowing of joint space may cause pain in the ball of the foot, which can be clearly diagnosed by X-ray. 2. Plantar fasciitis: due to chronic repeated pulling, causing plantar fascia tension, aseptic inflammation occurs, mainly walking or standing for a long time pain. 3. Metatarsal head osteochondromatosis: related to repeated stress stimulation or trauma, mainly for the pain of forefoot, metatarsophalangeal joint activity limitation. 4. Gout: sudden pain, accompanied by local redness and swelling, laboratory tests of uric acid can make a clear diagnosis. If the pain in the forefoot bone persists without relief, it is best to go to the orthopedic department of the hospital for examination to clarify the cause of the disease and further treatment.