Having a child with a negative closed antibody is related to a number of factors, such as genetic factors, environmental factors, bad habits and so on. The presence of a negative closed antibody is an anomaly, and there is a certain chance of infertility, which can cause repeated miscarriages, spontaneous abortions or fetal arrest. This is related to a number of factors, such as genetic factors, environmental factors, bad habits (bad living environment, bad dietary habits, psychological stress), etc., which can easily lead to negative antibodies. If a woman suffers from acute or chronic diseases, it will lead to a decline in immunity, causing autoimmune diseases, resulting in closed antibody deficiency, which may lead to recurrent miscarriages and habitual abortions during pregnancy. The emergence of closed antibody negative phenomenon, it is recommended to timely examination and treatment, can go to the local regular hospital for diagnosis.