Whether or not a ground-glass nodule with vacuoles is serious depends on the nature of the ground-glass nodule, which is not serious if it is benign and more serious if it is malignant. A ground-glass nodule with vacuoles is a cloudy density shadow with mildly increased density on imaging, and is accompanied by vacuoles inside the nodule. If the nodule is caused by bacteria, fungi or tuberculosis, it is a benign nodule, which is usually not too serious and can be treated under the guidance of a doctor. If the vacuoles in ground-glass nodules are caused by malignant tumors, such as lung cancer, then they are more serious and require timely treatment, such as surgery, chemotherapy, radiotherapy, targeted therapy and other methods to improve the prognosis. Therefore, when you find vacuoles in ground-glass nodules, you need to clarify the cause of the disease and treat it if necessary to avoid delaying the disease.