Colon polyps sampling biopsy and postoperative biopsy, the difference between the two mainly lies in the selection of tissue, diagnostic content and other aspects are different. 1. Selection of tissue: sampling biopsy, generally refers to the local anesthesia to take part of the polyp tissue sent to the pathological examination; postoperative pathology generally refers to the post-surgery, general anesthesia, the polyp together with some of the surrounding tissues, and even lymph nodes, fat and other tissues after complete excision of the pathology examination. 2. Diagnostic content: because the biopsy sampling is relatively small, there is a possibility of missed diagnosis, and generally can only do qualitative diagnosis; postoperative pathology due to the complete removal of the surrounding lymph nodes and fat tissues, so there is no possibility of missed diagnosis, the disease staging is more clear. Specifically which sampling method, it is recommended that patients should choose under the guidance of the doctor.